NFL Week 4 Odds, Picks and Predictions: Expert Breakdowns for Every Sunday and Monday Matchup

October has arrived, and with it comes a loaded Week 4 slate as contenders look to separate themselves from the rest of the pack. This week features the first of three London games on the schedule, extending Sunday's action, along with a renewed division rivalry on Monday Night Football. Below is a roundup of expert picks and betting insights for every Week 4 matchup, with lines courtesy of SportsLine consensus odds. Indianapolis Colts at Washington Commanders (London) Sunday, 9:30 a.m. ET (NFL Network) Line: Commanders -1.5, O/U 48.5 Both teams picked up their first win of the season last week before heading to London. CBS Sports' Pete Prisco expects a high-scoring affair, with Indianapolis pulling out a late win in a projected 31-30 thriller. New England Patriots at Buffalo Bills Sunday, 1 p.m. ET (CBS) Line: Bills -3, O/U 49.5 New England's post-Super Bowl struggles continued with a lopsided road loss to Jacksonville last week. Buffalo enters 3-0 but narrowly escaped a sloppy win over the Chargers in Week 3. SportsLine's Josh Nagel has detailed teaser selections for this matchup. New York Jets at Chicago Bears Sunday, 1 p.m. ET (FOX) Line: Bears -8.5, O/U 45.5 Chicago's strong rushing attack should carry the Bears to a home win, according to SportsLine's Eric Cohen, who's backing Chicago despite questions about whether the total will hit the Over. Jacksonville Jaguars at Cincinnati Bengals Sunday, 1 p.m. ET (CBS) Line: Bengals -2.5, O/U 51.5 Jaguars quarterback Trevor Lawrence has never beaten Cincinnati in three career meetings — the only team he's faced at least three times without a win. CBS Sports' John Breech is backing the Bengals in this AFC matchup between two 2-1 playoff hopefuls. Arizona Cardinals at New York Giants Sunday, 1 p.m. ET (CBS) Line: Giants -7, O/U 45.5 The Giants struggled offensively in brutal weather conditions during last week's win over Tennessee, while Arizona showed promise despite a road loss to San Francisco. Pete Prisco predicts an upset, with the Cardinals winning 24-21 at MetLife Stadium. Los Angeles Rams at Philadelphia Eagles Sunday, 1 p.m. ET (FOX) Line: Rams -1.5, O/U 47.5 Philadelphia's defense was exposed in a primetime loss to Chicago, and the Eagles remain the only team yet to score in the first quarter this season. CBS Sports' Jordan Dajani is picking the Rams to win 26-20 in Philadelphia. Green Bay Packers at Tampa Bay Buccaneers Sunday, 1 p.m. ET (FOX) Line: Packers -1.5, O/U 47.5 Both teams have struggled this season, but Green Bay could catch a break facing an undrafted rookie quarterback in Jalon Daniels. SportsLine's Eric Cohen likes the Packers not just to win, but to cover the spread. Tennessee Titans at Baltimore Ravens Sunday, 1 p.m. ET (CBS) Line: Ravens -8.5, O/U 47.5 Baltimore and Minnesota enter as two of the week's biggest favorites, making both popular survivor pool plays. SportsLine's R.J. White has strategy recommendations for navigating this week's survivor pool picks. Dallas Cowboys at Houston Texans Sunday, 1 p.m. ET (FOX) Line: Texans -2.5, O/U 47.5 Houston's offensive line remains a significant weakness, ranking near the bottom of the league in both pass protection and rushing efficiency. CBS Sports' Tyler Sullivan is picking Dallas to win outright against their in-state rival. Miami Dolphins at Minnesota Vikings Sunday, 4:05 p.m. ET (FOX) Line: Vikings -7.5, O/U 43.5 Miami's offense, already struggling, took a significant hit with the loss of star running back De'Von Achane. The Dolphins now face Minnesota's blitz-heavy defense, which leads the NFL in blitz rate. Tyler Sullivan likes the Vikings to cover the spread in this matchup.